Publications

2023/10/01

ScienceDirect

Outer membrane vesicle-based intranasal vaccines

Peter Van der Ley, Virgil EJC Schijns,

2023/08/04

Scientific Reports

In vitro alternatives for reactogenicity assessment of outer membrane vesicle based vaccines

Marijke W. A. Molenaar-de Backer, Paulien Doodeman, Fereshte Rezai, Lisa M. Verhagen, Arno van der Ark, Els M. Plagmeijer, Bernard Metz, Naomi van Vlies, Olga Ophorst & René H. M. Raeven.

2022/12/20

mSphere

Microencapsulated IL-12 Drives Genital Tract Immune Responses to Intranasal Gonococcal Outer Membrane Vesicle Vaccine and Induces Resistance to Vaginal Infection with Diverse Strains of Neisseria gonorrhoeae

Yingru Liu, Laura A Hammer, Jikke Daamen, Michiel Stork, Nejat K Egilmez, Michael W Russell

2021/12/01

Analytical Chemistry

Validation of an FFF-MALS Method to Characterize the Production and Functionalization of Outer-Membrane Vesicles for Conjugate Vaccines

Robert M F van der Put , Arnoud Spies, Bernard Metz, Daniel Some, Roger Scherrers, Roland Pieters, Maarten Danial

2021/12/01

Frontiers in Immunology

An Intranasal OMV-Based Vaccine Induces High Mucosal and Systemic Protecting Immunity Against a SARS-CoV-2 Infection

Peter van der Ley, Afshin Zariri, Elly van Riet, Dinja Oosterhoff, Corine Kruiswijk

2021/04/28

Vaccine

Vaccination with meningococcal outer membrane vesicles carrying Borrelia OspA protects against experimental Lyme borreliosis

PM J Klouwens, M L M Salverda, J J Trentelman, J I Ersoz, A Wagemakers, M J H Gerritzen, P A van der Ley, J W Hovius

2020/10/09

Vaccine

Shortening the Lipid A Acyl Chains of Bordetella pertussis Enables Depletion of Lipopolysaccharide Endotoxic Activity

Jesús Arenas, Elder Pupo, Coen Phielix, Dionne David, Afshin Zariri, Alla Zamyatina, Jan Tommassen, Peter van der Ley

2020/04/30

Scientific Reports

Intranasal immunization with outer membrane vesicle pertussis vaccine confers broad protection through mucosal IgA and Th17 responses

René H M Raeven , Dedeke Rockx-Brouwer, Gaurav Kanojia, Larissa van der Maas, Tim H E Bindels, Rimko Ten Have, Elly van Riet, Bernard Metz

2019/11/01

Applied Microbiology and Biotechnology

Continuous production of Neisseria meningitidis outer membrane vesicles

Matthias J H Gerritzen, Lilli Stangowez, Bas van de Waterbeemd, Dirk E Martens, René H Wijffels, Michiel Stork

2016/09/19

PubMed

Meningococcal Outer Membrane Vesicle Composition-Dependent Activation of the Innate Immune Response

Afshin Zariri, Joep Beskers, Bas van de Waterbeemd, Hendrik Jan Hamstra, Tim H E Bindels, Elly van Riet, Jos P M van Putten, Peter van der Ley

2013/01/23

International Journal of Pharmaceutics

Cysteine Depletion Causes Oxidative Stress and Triggers Outer Membrane Vesicle Release by Neisseria meningitidis; Implications for Vaccine Development

Bas van de Waterbeemd, Gijsbert Zomer, Jan van den Ijssel, Lonneke van Keulen, Michel H Eppink, Peter van der Ley, Leo A van der Pol

2010/07/05

ScienceDirect

Improved OMV vaccine against Neisseria meningitidis using genetically engineered strains and a detergent-free purification process

Bas van de Waterbeemd, Mathieu Streefland, Peter van der Ley, Bert Zomer, Harry van Dijken, Dirk Martens, René Wijffels, Leo van der Pol